Diane M. Thiboutot
Photo
Academic title Professor of Dermatology
College College of Medicine
Campuses Penn State Milton S. Hershey Medical Center
Department Dermatology
Graduate programs
Email Phone FAX
  dthiboutot@psu.edu
  717 531 8307
  717 531 6516
Educational background
  M.D., Pennsylvania State University College of Medicine, 1988
Internship, Penn State Milton S. Hershey Medical Center
Residency, Penn State Milton S. Hershey Medical Center
Research interests
 

Factors regulating human sebum production in acne

The goal of our research is to determine the factors that regulate lipid production in the skin and sebaceous glands. In this regard we are investigating the role of peroxisome proliferator activated receptors (PPARs) and steroid hormones in cell culture models of human sebocytes and keratinocytes.

Areas of expertise
 
Sebaceous GlandsRosacea
Acne VulgarisHair Follicle
EpidermisSkin Diseases
OxidoreductasesEndocrine System Diseases
Contraceptives, Oral, HormonalDermatologic Agents
LipidsContraceptives, Oral, Combined
Ethinyl EstradiolLevonorgestrel
Receptors, CorticotropinIsoenzymes
SkinTestosterone 5-alpha-Reductase
AlopeciaScalp
17-Hydroxysteroid DehydrogenasesQuality of Life
AndrogensDicarboxylic Acids
SteroidsEsophageal Diseases
EsophagusGastrointestinal Neoplasms
Hamartoma Syndrome, MultiplePhosphoric Monoester Hydrolases
PolypsTumor Suppressor Proteins
Androgen AntagonistsCondylomata Acuminata
Gene TherapyOligonucleotides, Antisense
Oncogene Proteins, ViralPapillomavirus Infections
DoxycyclineNaphthalenes
Anti-Inflammatory Agents, Non-SteroidalGene Expression Profiling
Gene Expression RegulationInflammation
Matrix MetalloproteinasesOligonucleotide Array Sequence Analysis
Anti-Bacterial AgentsRetinoids
PapillomaviridaeAcute-Phase Proteins
ApoptosisIsotretinoin
LipocalinsProto-Oncogene Proteins
CounselingPatient Compliance
Patient Education as TopicContraceptives, Oral
DermatologyGynecology
Interdisciplinary Communication
Publication author name
  Thiboutot D
Thiboutot DM
Select publications
  Thiboutot DM. Acne and rosacea. New and emerging therapies. 2000 Jan. Dermatol Clin. 18(1):63-71, viii.
Thiboutot D. New treatments and therapeutic strategies for acne. 2000 Feb. Arch Fam Med. 9(2):179-87.
Thiboutot D. Hormones and acne: pathophysiology, clinical evaluation, and therapies. 2001 Sep. Semin Cutan Med Surg. 20(3):144-53.
Thiboutot D. Thieroff-Ekerdt R. Graupe K. Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: results from two vehicle-controlled, randomized phase III studies. 2003 Jun. J Am Acad Dermatol. 48(6):836-45.
Thiboutot D. Jabara S. McAllister JM. Sivarajah A. Gilliland K. Cong Z. Clawson G. Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). 2003 Jun. J Invest Dermatol. 120(6):905-14.
National Institute of Child Health and Human Development
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Research techniques
 
Reverse Transcriptase Polymerase Chain ReactionCell Culture Techniques
Oligonucleotide Array Sequence AnalysisImmunohistochemistry
also ...
 All publications