Patricia J. McLaughlin All publications ( 187 ) Zagon IS. Donahue RN. Rogosnitzky M. McLaughlin PJ. Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function. 2008 Aug. Exp Biol Med (Maywood). 233(8):968-79. Zagon IS. Klocek MS. Griffith JW. Sassani JW. Komáromy AM. McLaughlin PJ. Prevention of exuberant granulation tissue and neovascularization in the rat cornea by naltrexone. 2008 Apr. Arch Ophthalmol. 126(4):501-6. Cheng F. Zagon IS. Verderame MF. McLaughlin PJ. The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer. 2007 Nov 1. Cancer Res. 67(21):10511-8. McLaughlin PJ. Verderame MF. Hankins JL. Zagon IS. Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck. 2007 Mar. Int J Mol Med. 19(3):421-8. Zagon IS. Rahn KA. McLaughlin PJ. Opioids and migration, chemotaxis, invasion, and adhesion of human cancer cells. 2007 Dec. Neuropeptides. 41(6):441-52. Zagon IS. Klocek MS. Sassani JW. McLaughlin PJ. Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus. 2007 Aug. Arch Ophthalmol. 125(8):1082-8. Zagon IS. Sassani JW. Myers RL. McLaughlin PJ. Naltrexone accelerates healing without compromise of adhesion complexes in normal and diabetic corneal epithelium. 2007 Apr 2. Brain Res Bull. 72(1):18-24. National Eye Institute Zagon IS. Verderame MF. Hankins J. McLaughlin PJ. Overexpression of the opioid growth factor receptor potentiates growth inhibition in human pancreatic cancer cells. 2007 Apr. Int J Oncol. 30(4):775-83. Klocek MS. Sassani JW. McLaughlin PJ. Zagon IS. Topically applied naltrexone restores corneal reepithelialization in diabetic rats. 2007 Apr. J Ocul Pharmacol Ther. 23(2):89-102. National Eye Institute Zagon IS. Klocek MS. Sassani JW. Mauger DT. McLaughlin PJ. Corneal safety of topically applied naltrexone. 2006 Oct. J Ocul Pharmacol Ther. 22(5):377-87. National Eye Institute Zagon IS. Sassani JW. Malefyt KJ. McLaughlin PJ. Regulation of corneal repair by particle-mediated gene transfer of opioid growth factor receptor complementary DNA. 2006 Nov. Arch Ophthalmol. 124(11):1620-4. National Eye Institute McLaughlin PJ. Zagon IS. Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor. 2006 Jun. Int J Oncol. 28(6):1577-83. Zagon IS. Sassani JW. McLaughlin PJ. Adaptation of homeostatic ocular surface epithelium to chronic treatment with the opioid antagonist naltrexone. 2006 Aug. Cornea. 25(7):821-9. National Eye Institute Zagon IS. McLaughlin PJ. Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers. 2006 Aug. Int J Oncol. 29(2):489-94. Zagon IS. Sassani JW. McLaughlin PJ. Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats. 2006 Apr. Diabetes. 55(4):1141-7. National Eye Institute Zagon IS. McLaughlin PJ. Opioids and differentiation in human cancer cells. 2005 Oct. Neuropeptides. 39(5):495-505. Zagon IS. Jaglowski JR. Verderame MF. Smith JP. Leure-Dupree AE. McLaughlin PJ. Combination chemotherapy with gemcitabine and biotherapy with opioid growth factor (OGF) enhances the growth inhibition of pancreatic adenocarcinoma. 2005 Nov. Cancer Chemother Pharmacol. 56(5):510-20. McLaughlin PJ. Jaglowski JR. Verderame MF. Stack BC. Leure-Dupree AE. Zagon IS. Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of paclitaxel and opioid growth factor. 2005 Mar. Int J Oncol. 26(3):809-16. Jaglowski JR. Zagon IS. Stack BC. Verderame MF. Leure-duPree AE. Manning JD. McLaughlin PJ. Opioid growth factor enhances tumor growth inhibition and increases the survival of paclitaxel-treated mice with squamous cell carcinoma of the head and neck. 2005 Jul. Cancer Chemother Pharmacol. 56(1):97-104. Zagon IS. Sassani JW. Verderame MF. McLaughlin PJ. Particle-mediated gene transfer of opioid growth factor receptor cDNA regulates cell proliferation of the corneal epithelium. 2005 Jul. Cornea. 24(5):614-9. National Eye Institute Zagon IS. Ruth TB. McLaughlin PJ. Nucleocytoplasmic distribution of opioid growth factor and its receptor in tongue epithelium. 2005 Jan. Anat Rec A Discov Mol Cell Evol Biol. 282(1):24-37. Zagon IS. McLaughlin PJ. Gene expression of OGFr in the developing and adult rat brain and cerebellum. 2004 Mar 1. Brain Res Bull. 63(1):57-63. Smith JP. Conter RL. Bingaman SI. Harvey HA. Mauger DT. Ahmad M. Demers LM. Stanley WB. McLaughlin PJ. Zagon IS. Treatment of advanced pancreatic cancer with opioid growth factor: phase I. 2004 Mar. Anticancer Drugs. 15(3):203-9. National Cancer Institute National Center for Research Resources Zagon IS. McLaughlin PJ. Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cells. 2004 Jun. Int J Oncol. 24(6):1443-8. McLaughlin PJ. Stack BC. Braine KM. Ruda JD. Zagon IS. Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administration. 2004 Jan. Int J Oncol. 24(1):227-32. McLaughlin PJ. Levin RJ. Zagon IS. Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice. 2003 Sep 25. Cancer Lett. 199(2):209-17. Zagon IS. Verderame MF. McLaughlin PJ. The expression and function of the OGF-OGFr axis - a tonically active negative regulator of growth - in COS cells. 2003 Oct. Neuropeptides. 37(5):290-7. Sassani JW. Zagon IS. McLaughlin PJ. Opioid growth factor modulation of corneal epithelium: uppers and downers. 2003 May. Curr Eye Res. 26(5):249-62. Zagon IS. Ruth TB. Leure-duPree AE. Sassani JW. McLaughlin PJ. Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea. 2003 Mar 28. Brain Res. 967(1-2):37-47. National Eye Institute Zagon IS. Essis FM. Verderame MF. Healy DA. Atnip RG. McLaughlin PJ. Opioid growth factor inhibits intimal hyperplasia in balloon-injured rat carotid artery. 2003 Mar. J Vasc Surg. 37(3):636-43. McLaughlin PJ. Stack BC. Levin RJ. Fedok F. Zagon IS. Defects in the opioid growth factor receptor in human squamous cell carcinoma of the head and neck. 2003 Apr 1. Cancer. 97(7):1701-10. Zagon IS. McLaughlin PJ. Opioids and the apoptotic pathway in human cancer cells. 2003 Apr. Neuropeptides. 37(2):79-88. Zagon IS. Jenkins JB. Sassani JW. Wylie JD. Ruth TB. Fry JL. Lang CM. McLaughlin PJ. Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat. 2002 Oct. Diabetes. 51(10):3055-62. National Eye Institute National Center for Research Resources Blebea J. Vu JH. Assadnia S. McLaughlin PJ. Atnip RG. Zagon IS. Differential effects of vascular growth factors on arterial and venous angiogenesis. 2002 Mar. J Vasc Surg. 35(3):532-8. National Cancer Institute McLaughlin PJ. Wylie JD. Bloom G. Griffith JW. Zagon IS. Chronic exposure to the opioid growth factor, [Met5]-enkephalin, during pregnancy: maternal and preweaning effects. 2002 Jan-Feb. Pharmacol Biochem Behav. 71(1-2):171-81. Zagon IS. Verderame MF. McLaughlin PJ. The biology of the opioid growth factor receptor (OGFr). 2002 Feb. Brain Res Brain Res Rev. 38(3):351-76. National Cancer Institute National Eye Institute Smith JP. Verderame MF. McLaughlin P. Martenis M. Ballard E. Zagon IS. Characterization of the CCK-C (cancer) receptor in human pancreatic cancer. 2002 Dec. Int J Mol Med. 10(6):689-94. National Cancer Institute McLaughlin PJ. Exposure to the opioid antagonist naltrexone throughout gestation alters postnatal heart development. 2002. Biol Neonate. 82(3):207-16. National Heart, Lung, and Blood Institute Zagon IS. Sassani JW. Ruth TB. McLaughlin PJ. Epithelial adhesion complexes and organ culture of the human cornea. 2001 May 11. Brain Res. 900(2):205-13. National Eye Institute Zagon IS. Wylie JD. Hurst WJ. McLaughlin PJ. Transplacental transfer of the opioid growth factor, [Met(5)]-enkephalin, in rats. 2001 Jun. Brain Res Bull. 55(3):341-6. Zagon IS. Sassani JW. Ruth TB. McLaughlin PJ. Cellular dynamics of corneal wound re-epithelialization in the rat. III. Mitotic activity. 2000 Nov 3. Brain Res. 882(1-2):169-79. National Eye Institute Zagon IS. Roesener CD. Verderame MF. Ohlsson-Wilhelm BM. Levin RJ. McLaughlin PJ. Opioid growth factor regulates the cell cycle of human neoplasias. 2000 Nov. Int J Oncol. 17(5):1053-61. National Cancer Institute Zalys R. Zagon IS. Bonneau RH. Lang CM. McLaughlin PJ. In vivo effects of chronic treatment with [MET5]-enkephalin on hematological values and natural killer cell activity in athymic mice. 2000 Jan 21. Life Sci. 66(9):829-34. National Cancer Institute Zagon IS. Sassani JW. McLaughlin PJ. Reepithelialization of the human cornea is regulated by endogenous opioids. 2000 Jan. Invest Ophthalmol Vis Sci. 41(1):73-81. National Eye Institute Zagon IS. Smith JP. Conter R. McLaughlin PJ. Identification and characterization of opioid growth factor receptor in human pancreatic adenocarcinoma. 2000 Jan. Int J Mol Med. 5(1):77-84. National Cancer Institute Zagon IS. Verderame MF. Allen SS. McLaughlin PJ. Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. 2000 Feb 21. Brain Res. 856(1-2):75-83. National Cancer Institute McLaughlin PJ. Levin RJ. Zagon IS. The opioid growth factor receptor in human head and neck squamous cell carcinoma. 2000 Feb. Int J Mol Med. 5(2):191-6. Zagon IS. Verderame MF. Zimmer WE. McLaughlin PJ. Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse. 2000 Dec 8. Brain Res Mol Brain Res. 84(1-2):106-14. National Cancer Institute National Eye Institute Smith JP. Conter RL. Demers TM. McLaughlin PJ. Zagon IS. Elevated levels of opioid growth factor in the plasma of patients with pancreatic cancer. 2000 Aug. Pancreas. 21(2):158-64. National Cancer Institute Blebea J. Mazo JE. Kihara TK. Vu JH. McLaughlin PJ. Atnip RG. Zagon IS. Opioid growth factor modulates angiogenesis. 2000 Aug. J Vasc Surg. 32(2):364-73. Wilson RP. McLaughlin PJ. Lang CM. Zagon IS. The opioid growth factor, [Met5]-enkephalin, inhibits DNA synthesis during recornification of mouse tail skin. 2000 Apr. Cell Prolif. 33(2):63-73. McLaughlin PJ. Levin RJ. Zagon IS. Regulation of human head and neck squamous cell carcinoma growth in tissue culture by opioid growth factor. 1999 May. Int J Oncol. 14(5):991-8. Zagon IS. Sassani JW. McLaughlin PJ. Cellular dynamics of corneal wound re-epithelialization in the rat. I. Fate of ocular surface epithelial cells synthesizing DNA prior to wounding. 1999 Mar 20. Brain Res. 822(1-2):149-63. National Eye Institute Zagon IS. Smith JP. McLaughlin PJ. Human pancreatic cancer cell proliferation in tissue culture is tonically inhibited by opioid growth factor. 1999 Mar. Int J Oncol. 14(3):577-84. National Cancer Institute McLaughlin PJ. Zagon IS. Skitzki J. Human neuroblastoma cell growth in tissue culture is regulated by opioid growth factor. 1999 Feb. Int J Oncol. 14(2):373-80. Zagon IS. Verderame MF. Allen SS. McLaughlin PJ. Cloning, sequencing, expression and function of a cDNA encoding a receptor for the opioid growth factor, [Met(5)]enkephalin. 1999 Dec 4. Brain Res. 849(1-2):147-54. National Cancer Institute National Institute of Neurological Disorders and Stroke Bisignani GJ. McLaughlin PJ. Ordille SD. Beltz MS. Jarowenko MV. Zagon IS. Human renal cell cancer proliferation in tissue culture is tonically inhibited by opioid growth factor. 1999 Dec. J Urol. 162(6):2186-91. Zagon IS. Wu Y. McLaughlin PJ. Opioid growth factor and organ development in rat and human embryos. 1999 Aug 28. Brain Res. 839(2):313-22. National Eye Institute National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. Sassani JW. McLaughlin PJ. Cellular dynamics of corneal wound re-epithelialization in the rat. II. DNA synthesis of the ocular surface epithelium following wounding. 1999 Aug 28. Brain Res. 839(2):243-52. National Eye Institute Wilson RP. McLaughlin PJ. Lang CM. Zagon IS. Temporal variation in cellular proliferation during recornification of mouse tail skin. 1998 Oct-Dec. Cell Prolif. 31(5-6):191-201. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke McLaughlin PJ. Allar MA. Preproenkephalin gene expression and [Met5]-enkephalin levels in the developing rat heart. 1998 Oct 1. Brain Res Mol Brain Res. 60(2):160-7. National Heart, Lung, and Blood Institute Zagon IS. Sassani JW. Wu Y. McLaughlin PJ. The autocrine derivation of the opioid growth factor, [Met5]-enkephalin, in ocular surface epithelium. 1998 May 4. Brain Res. 792(1):72-8. National Eye Institute Zagon IS. Sassani JW. McLaughlin PJ. Re-epithelialization of the rat cornea is accelerated by blockade of opioid receptors. 1998 Jul 6. Brain Res. 798(1-2):254-60. National Eye Institute Zagon IS. Tobias SW. Hytrek SD. McLaughlin PJ. Opioid receptor blockade throughout prenatal life confers long-term insensitivity to morphine and alters mu opioid receptors. 1998 Jan. Pharmacol Biochem Behav. 59(1):201-7. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke McLaughlin PJ. Wu Y. Opioid gene expression in the developing and adult rat heart. 1998 Feb. Dev Dyn. 211(2):153-63. National Heart, Lung, and Blood Institute Smith JP. Shih AH. Wotring MG. McLaughlin PJ. Zagon IS. Characterization of CCK-B/gastrin-like receptors in human gastric carcinoma. 1998 Feb. Int J Oncol. 12(2):411-9. National Cancer Institute Zagon IS. Sassani JW. McLaughlin PJ. Re-epithelialization of the rabbit cornea is regulated by opioid growth factor. 1998 Aug 24. Brain Res. 803(1-2):61-8. National Eye Institute Wu Y. McLaughlin PJ. Zagon IS. Ontogeny of the opioid growth factor, [Met5]-enkephalin, preproenkephalin gene expression, and the zeta opioid receptor in the developing and adult aorta of rat. 1998 Apr. Dev Dyn. 211(4):327-37. National Heart, Lung, and Blood Institute Zagon IS. Hurst WJ. McLaughlin PJ. Naltrexone is not detected in preweaning rats following transplacental exposure: implications for growth modulation. 1998. Life Sci. 62(3):221-8. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke McLaughlin PJ. Tobias SW. Lang CM. Zagon IS. Chronic exposure to the opioid antagonist naltrexone during pregnancy: maternal and offspring effects. 1997 Sep. Physiol Behav. 62(3):501-8. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Levin RJ. Wu Y. McLaughlin PJ. Zagon IS. Expression of the opioid growth factor, [Met5]-enkephalin, and the zeta opioid receptor in head and neck squamous cell carcinoma. 1997 Mar. Laryngoscope. 107(3):335-9. National Institute of Neurological Disorders and Stroke Zagon IS. Sassani JW. Kane ER. McLaughlin PJ. Homeostasis of ocular surface epithelium in the rat is regulated by opioid growth factor. 1997 Jun 6. Brain Res. 759(1):92-102. National Eye Institute McLaughlin PJ. Wu Y. Identification and characterization of the zeta-opioid receptor in developing rat heart. 1997 Jun. Am J Physiol. 272(6 Pt 2):R1841-6. National Heart, Lung, and Blood Institute Zagon IS. Hytrek SD. Smith JP. McLaughlin PJ. Opioid growth factor (OGF) inhibits human pancreatic cancer transplanted into nude mice. 1997 Jan 30. Cancer Lett. 112(2):167-75. National Cancer Institute National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke McLaughlin PJ. Tobias SW. Lang CM. Zagon IS. Opioid receptor blockade during prenatal life modifies postnatal behavioral development. 1997 Dec. Pharmacol Biochem Behav. 58(4):1075-82. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. Wu Y. McLaughlin PJ. Opioid growth factor is present in human and mouse gastrointestinal tract and inhibits DNA synthesis. 1997 Apr. Am J Physiol. 272(4 Pt 2):R1094-104. National Cancer Institute National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. Tobias SW. McLaughlin PJ. Endogenous opioids and prenatal determinants of neuroplasticity. 1997. Adv Exp Med Biol. 429:289-303. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. Hurst WJ. McLaughlin PJ. Transplacental transfer of naltrexone in rats. 1997. Life Sci. 61(13):1261-7. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. Hurst WJ. McLaughlin PJ. Identification of [Met5]-enkephalin in developing, adult, and renewing tissues by reversed-phase high performance liquid chromatography and radioimmunoassay. 1997. Life Sci. 61(4):363-70. National Eye Institute National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Smith JP. Stock EA. Wotring MG. McLaughlin PJ. Zagon IS. Characterization of the CCK-B/gastrin-like receptor in human colon cancer. 1996 Sep. Am J Physiol. 271(3 Pt 2):R797-805. National Cancer Institute Zagon IS. Hytrek SD. Lang CM. Smith JP. McGarrity TJ. Wu Y. McLaughlin PJ. Opioid growth factor ([Met5]enkephalin) prevents the incidence and retards the growth of human colon cancer. 1996 Sep. Am J Physiol. 271(3 Pt 2):R780-6. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. Hytrek SD. McLaughlin PJ. Opioid growth factor tonically inhibits human colon cancer cell proliferation in tissue culture. 1996 Sep. Am J Physiol. 271(3 Pt 2):R511-8. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Smith JP. Shih A. Wu Y. McLaughlin PJ. Zagon IS. Gastrin regulates growth of human pancreatic cancer in a tonic and autocrine fashion. 1996 May. Am J Physiol. 270(5 Pt 2):R1078-84. National Cancer Institute Hytrek SD. McLaughlin PJ. Lang CM. Zagon IS. Inhibition of human colon cancer by intermittent opioid receptor blockade with naltrexone. 1996 Mar 29. Cancer Lett. 101(2):159-64. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke National Center for Research Resources Zagon IS. Wu Y. McLaughlin PJ. The opioid growth factor, [Met5]-enkephalin, and the zeta opioid receptor are present in human and mouse skin and tonically act to inhibit DNA synthesis in the epidermis. 1996 Mar. J Invest Dermatol. 106(3):490-7. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Isayama T. McLaughlin PJ. Zagon IS. Ontogeny of preproenkephalin mRNA expression in the rat retina. 1996 Jul-Aug. Vis Neurosci. 13(4):695-704. National Institute of Neurological Disorders and Stroke McLaughlin PJ. Regulation of DNA synthesis of myocardial and epicardial cells in developing rat heart by [Met5]enkephalin. 1996 Jul. Am J Physiol. 271(1 Pt 2):R122-9. National Heart, Lung, and Blood Institute Hytrek SD. Smith JP. McGarrity TJ. McLaughlin PJ. Lang CM. Zagon IS. Identification and characterization of zeta-opioid receptor in human colon cancer. 1996 Jul. Am J Physiol. 271(1 Pt 2):R115-21. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke National Center for Research Resources Zagon IS. Wu Y. McLaughlin PJ. Opioid growth factor-dependent DNA synthesis in the neonatal rat aorta. 1996 Jan. Am J Physiol. 270(1 Pt 2):R22-32. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Isayama T. Hurst WJ. McLaughlin PJ. Zagon IS. Ontogeny of the opioid growth factor, [Met5]-enkephalin, and its binding activity in the rat retina. 1995 Sep-Oct. Vis Neurosci. 12(5):939-50. National Institute of Neurological Disorders and Stroke Ciocco GM. Moschel RC. Chae MY. McLaughlin PJ. Zagon IS. Pegg AE. Specific labeling of O6-alkylguanine-DNA alkyltransferase by reaction with O6-(p-hydroxy[3H]methylbenzyl)guanine. 1995 Sep 15. Cancer Res. 55(18):4085-91. National Cancer Institute Zagon IS. McLaughlin PJ. Gene-peptide relationships in the developing rat brain: the response of preproenkephalin mRNA and [Met5]-enkephalin to acute opioid antagonist (naltrexone) exposure. 1995 Oct. Brain Res Mol Brain Res. 33(1):111-20. National Institute of Neurological Disorders and Stroke Zagon IS. Sassani JW. Allison G. McLaughlin PJ. Conserved expression of the opioid growth factor, [Met5]enkephalin, and the zeta (zeta) opioid receptor in vertebrate cornea. 1995 Feb 6. Brain Res. 671(1):105-11. National Institute of Neurological Disorders and Stroke Zagon IS. Sassani JW. McLaughlin PJ. Opioid growth factor modulates corneal epithelial outgrowth in tissue culture. 1995 Apr. Am J Physiol. 268(4 Pt 2):R942-50. National Institute of Neurological Disorders and Stroke Zagon IS. Wu Y. McLaughlin PJ. Opioid growth factor inhibits DNA synthesis in mouse tongue epithelium in a circadian rhythm-dependent manner. 1994 Sep. Am J Physiol. 267(3 Pt 2):R645-52. National Institute of Neurological Disorders and Stroke Zagon IS. Wu Y. McLaughlin PJ. Opioid antagonist modulation of DNA synthesis in mouse tongue epithelium is circadian dependent. 1994 Jul. Pharmacol Biochem Behav. 48(3):709-14. National Institute of Neurological Disorders and Stroke Smith JP. Liu G. Soundararajan V. McLaughlin PJ. Zagon IS. Identification and characterization of CCK-B/gastrin receptors in human pancreatic cancer cell lines. 1994 Jan. Am J Physiol. 266(1 Pt 2):R277-83. National Cancer Institute Zagon IS. Isayama T. McLaughlin PJ. Preproenkephalin mRNA expression in the developing and adult rat brain. 1994 Jan. Brain Res Mol Brain Res. 21(1-2):85-98. National Institute of Neurological Disorders and Stroke McLaughlin PJ. Opioid antagonist modulation of rat heart development. 1994. Life Sci. 54(19):1423-31. Zagon IS. Goodman SR. McLaughlin PJ. Zeta (zeta), the opioid growth factor receptor: identification and characterization of binding subunits. 1993 Mar 5. Brain Res. 605(1):50-6. National Institute of Neurological Disorders and Stroke Smith JP. Rickabaugh CA. McLaughlin PJ. Zagon IS. Cholecystokinin receptors and PANC-1 human pancreatic cancer cells. 1993 Jul. Am J Physiol. 265(1 Pt 1):G149-55. National Cancer Institute McLaughlin PJ. Aikawa A. Davies HM. Ward RG. Bakran A. Sells RA. Johnson PM. Uromodulin levels are decreased in urine during acute tubular necrosis but not during immune rejection after renal transplantation. 1993 Feb. Clin Sci (Lond). 84(2):243-6. Zagon IS. McLaughlin PJ. Production and characterization of polyclonal and monoclonal antibodies to the zeta (zeta) opioid receptor. 1993 Dec 10. Brain Res. 630(1-2):295-302. National Institute of Neurological Disorders and Stroke Zagon IS. Gibo DM. McLaughlin PJ. Ontogeny of zeta (zeta), the opioid growth factor receptor, in the rat brain. 1992 Nov 20. Brain Res. 596(1-2):149-56. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. An opioid growth factor regulates the replication of microorganisms. 1992. Life Sci. 50(16):1179-87. National Institute of Neurological Disorders and Stroke Isayama T. McLaughlin PJ. Zagon IS. Endogenous opioids regulate cell proliferation in the retina of developing rat. 1991 Mar 22. Brain Res. 544(1):79-85. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Identification of opioid peptides regulating proliferation of neurons and glia in the developing nervous system. 1991 Mar 1. Brain Res. 542(2):318-23. National Institute of Neurological Disorders and Stroke Zagon IS. Gibo DM. McLaughlin PJ. Zeta (zeta), a growth-related opioid receptor in developing rat cerebellum: identification and characterization. 1991 Jun 14. Brain Res. 551(1-2):28-35. National Institute of Neurological Disorders and Stroke Zagon IS. Goodman SR. McLaughlin PJ. Demonstration and characterization of zeta (zeta), a growth-related opioid receptor, in a neuroblastoma cell line. 1990 Mar 19. Brain Res. 511(2):181-6. National Institute of Neurological Disorders and Stroke Zagon IS. Gibo DM. McLaughlin PJ. Adult and developing human cerebella exhibit different profiles of opioid binding sites. 1990 Jul 16. Brain Res. 523(1):62-8. National Institute of Neurological Disorders and Stroke Zagon IS. Gibo D. McLaughlin PJ. Expression of zeta (zeta), a growth-related opioid receptor, in metastatic adenocarcinoma of the human cerebellum. 1990 Feb 21. J Natl Cancer Inst. 82(4):325-7. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Ultrastructural localization of enkephalin-like immunoreactivity in developing rat cerebellum. 1990. Neuroscience. 34(2):479-89. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Opioid antagonist (naltrexone) stimulation of cell proliferation in human and animal neuroblastoma and human fibrosarcoma cells in culture. 1990. Neuroscience. 37(1):223-6. National Institute of Neurological Disorders and Stroke Zagon IS. Goodman SR. McLaughlin PJ. Characterization of zeta (zeta): a new opioid receptor involved in growth. 1989 Mar 20. Brain Res. 482(2):297-305. National Institute of Neurological Disorders and Stroke Hauser KF. McLaughlin PJ. Zagon IS. Endogenous opioid systems and the regulation of dendritic growth and spine formation. 1989 Mar 1. J Comp Neurol. 281(1):13-22. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Endogenous opioid systems regulate growth of neural tumor cells in culture. 1989 Jun 19. Brain Res. 490(1):14-25. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Naloxone modulates body and organ growth of rats: dependency on the duration of opioid receptor blockade and stereospecificity. 1989 Jun. Pharmacol Biochem Behav. 33(2):325-8. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Opioid antagonist modulation of murine neuroblastoma: a profile of cell proliferation and opioid peptides and receptors. 1989 Feb 20. Brain Res. 480(1-2):16-28. National Institute of Neurological Disorders and Stroke Zagon IS. Zagon E. McLaughlin PJ. Opioids and the developing organism: a comprehensive bibliography, 1984-1988. 1989. Neurosci Biobehav Rev. 13(4):207-35. National Institute of Neurological Disorders and Stroke Zagon IS. Goodman SR. McLaughlin PJ. Characterization of opioid binding sites in murine neuroblastoma. 1988 May 24. Brain Res. 449(1-2):80-8. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin P. Endogenous opioids and the growth regulation of a neural tumor. 1988. Life Sci. 43(16):1313-8. National Institute of Neurological Disorders and Stroke McLaughlin PJ. Zagon IS. Modulation of human neuroblastoma transplanted into nude mice by endogenous opioid systems. 1987 Sep 21. Life Sci. 41(12):1465-72. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Goodman SR. Rhodes RE. Opioid receptors and endogenous opioids in diverse human and animal cancers. 1987 Nov. J Natl Cancer Inst. 79(5):1059-65. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Endogenous opioid systems regulate cell proliferation in the developing rat brain. 1987 May 26. Brain Res. 412(1):68-72. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. The location and orientation of mitotic figures during histogenesis of the rat cerebellar cortex. 1987 Mar. Brain Res Bull. 18(3):325-36. National Institute of Neurological Disorders and Stroke Hauser KF. McLaughlin PJ. Zagon IS. Endogenous opioids regulate dendritic growth and spine formation in developing rat brain. 1987 Jul 21. Brain Res. 416(1):157-61. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Modulation of murine neuroblastoma in nude mice by opioid antagonists. 1987 Jan. J Natl Cancer Inst. 78(1):141-7. National Institute of Neurological Disorders and Stroke Goodman SR. Zagon IS. Coleman DB. McLaughlin PJ. Spectrin expression in neuroblastoma cells. 1986 May. Brain Res Bull. 16(5):597-602. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Opioid antagonist (naltrexone) modulation of cerebellar development: histological and morphometric studies. 1986 May. J Neurosci. 6(5):1424-32. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. beta-Funaltrexamine (beta-FNA) and the regulation of body and brain development in rats. 1986 Jul. Brain Res Bull. 17(1):5-9. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Opioid antagonist-induced modulation of cerebral and hippocampal development: histological and morphometric studies. 1986 Aug. Brain Res. 393(2):233-46. National Institute of Neurological Disorders and Stroke Zagon IS. Rhodes RE. McLaughlin PJ. Localization of enkephalin immunoreactivity in diverse tissues and cells of the developing and adult rat. 1986. Cell Tissue Res. 246(3):561-5. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Takemori AE. Portoghese PS. beta-Funaltrexamine (beta-FNA) and neural tumor response in mice. 1985 Oct 8. Eur J Pharmacol. 116(1-2):165-9. National Institute of Neurological Disorders and Stroke Zagon IS. Vaughn BV. McLaughlin PJ. Balaban CD. Localization of methadone in the brain of young rats by computer-assisted autoradiography. 1985 Oct. Neurosci Res. 3(1):1-19. National Institute of Neurological Disorders and Stroke Zagon IS. Rhodes RE. McLaughlin PJ. Distribution of enkephalin immunoreactivity in germinative cells of developing rat cerebellum. 1985 Mar 1. Science. 227(4690):1049-51. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Naltrexone's influence on neurobehavioral development. 1985 Mar. Pharmacol Biochem Behav. 22(3):441-8. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Stereospecific modulation of tumorigenicity by opioid antagonists. 1985 Jul 11. Eur J Pharmacol. 113(1):115-20. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Opioid antagonist-induced regulation of organ development. 1985 Apr. Physiol Behav. 34(4):507-11. National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Rogers WE. Neuronal migration independent of glial guidance: light and electron microscopic studies in the cerebellar cortex of neonatal rats. 1985. Acta Anat (Basel). 122(2):77-86. Casoria LA. Zagon IS. Bernstein SE. Shohet SB. McLaughlin PJ. Goodman SR. Normal content of brain spectrin-like protein in sph/sph mice. 1984 Oct. Br J Haematol. 58(2):277-88. National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke McLaughlin PJ. Stuart DI. Klein HW. Oikonomakos NG. Johnson LN. Substrate-cofactor interactions for glycogen phosphorylase b: a binding study in the crystal with heptenitol and heptulose 2-phosphate. 1984 Nov 20. Biochemistry. 23(24):5862-73. Zagon IS. McLaughlin PJ. Naltrexone modulates body and brain development in rats: a role for endogenous opioid systems in growth. 1984 Nov 12. Life Sci. 35(20):2057-64. Zagon IS. McLaughlin PJ. Opioids alter tumor cell growth and differentiation in vitro. 1984 Mar. NIDA Res Monogr. 49:344-50. National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Perinatal exposure to methadone alters sensitivity to drugs in adult rats. 1984 Jul-Aug. Neurobehav Toxicol Teratol. 6(4):319-23. Zagon IS. McLaughlin PJ. Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma: a role for endogenous opioid systems in cancer. 1984 Jul 23. Life Sci. 35(4):409-16. National Institute of Neurological Disorders and Stroke Goodman SR. Zagon IS. Whitfield CF. Casoria LA. Shohet SB. Bernstein SE. McLaughlin PJ. Laskiewicz TL. A spectrin-like protein from mouse brain membranes: phosphorylation of the 235,000-dalton subunit. 1984 Jul. Am J Physiol. 247(1 Pt 1):C61-73. National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Goodman SR. Localization of spectrin in mammalian brain. 1984 Dec. J Neurosci. 4(12):3089-100. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Zagon E. Opiates, endorphins, and the developing organism: a comprehensive bibliography, 1982-1983. 1984. Neurosci Biobehav Rev. 8(3):387-403. Zagon IS. McLaughlin PJ. Seely JE. Hoeksema GW. Pegg AE. Autoradiographic localization of ornithine decarboxylase in mouse kidney by use of radiolabeled alpha-difluoromethylornithine. 1984. Cell Tissue Res. 235(2):371-7. National Cancer Institute National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Increased brain size and cellular content in infant rats treated with an opiate antagonist. 1983 Sep 16. Science. 221(4616):1179-80. Zagon IS. McLaughlin PJ. Opioid antagonists inhibit the growth of metastatic murine neuroblastoma. 1983 Nov. Cancer Lett. 21(1):89-94. Zagon IS. McLaughlin PJ. Naltrexone modulates growth in infant rats. 1983 Dec 12. Life Sci. 33(24):2449-54. Zagon IS. McLaughlin PJ. Naltrexone modulates tumor response in mice with neuroblastoma. 1983 Aug 12. Science. 221(4611):671-3. Zagon IS. McLaughlin PJ. Somatic and neurobiological alterations in the progeny of female rats treated with methadone prior to mating. 1983 Apr. NIDA Res Monogr. 43:184-9. National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Behavioral effects of prenatal exposure to opiates. 1983. Monogr Neural Sci. 9:159-68. National Institute on Drug Abuse Goodman SR. Zagon IS. Whitfield CF. Casoria LA. McLaughlin PJ. Laskiewicz TL. A spectrin-like protein from mouse brain membranes: immunological and structural correlations with erythrocyte spectrin. 1983. Cell Motil. 3(5-6):635-47. National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. McLaughlin PJ. Neuronal cell deficits following exposure to methadone in rats. 1982 Oct 15. Experientia. 38(10):1214-6. National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Analgesia in young and adult rats perinatally exposed to methadone. 1982 Jul-Aug. Neurobehav Toxicol Teratol. 4(4):455-7. National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Effect of chronic heroin exposure on pregnant rats and their offspring. 1982 Apr. NIDA Res Monogr. 41:488-94. National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Comparative effects of postnatal undernutrition and methadone exposure on protein and nucleic acid contents of the brain and cerebellum in rats. 1982. Dev Neurosci. 5(5-6):385-93. National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Weaver DJ. Zagon E. Opiates, endorphins and the developing organism: a comprehensive bibliography. 1982. Neurosci Biobehav Rev. 6(4):439-79. National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Enhanced sensitivity to methadone in adult rats perinatally exposed to methadone. 1981 Sep 14. Life Sci. 29(11):1137-42. National Aeronautics and Space Agency Zagon IS. McLaughlin PJ. Nucleic acids and protein in brains and cerebella of rats transplacentally exposed to ethylnitrosourea. 1981 May. Brain Res Bull. 6(5):355-60. National Cancer Institute Zagon IS. McLaughlin PJ. Naloxone prolongs the survival time of mice treated with neuroblastoma. 1981 Mar 9. Life Sci. 28(10):1095-102. National Cancer Institute National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Heroin prolongs survival time and retards tumor growth in mice with neuroblastoma. 1981 Jul. Brain Res Bull. 7(1):25-32. National Cancer Institute National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Withdrawal-like symptoms in young and adult rats maternally exposed to methadone. 1981 Dec. Pharmacol Biochem Behav. 15(6):887-94. National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Protracted analgesia in young and adult rats maternally exposed to methadone. 1980 Mar 15. Experientia. 36(3):329-30. McLaughlin PJ. Zagon IS. Body and organ development of young rats maternally exposed to methadone. 1980. Biol Neonate. 38(3-4):185-96. National Institute on Drug Abuse Zagon IS. McLaughlin PJ. Thompson CI. Development of motor activity in young rats following perinatal methadone exposure. 1979 May. Pharmacol Biochem Behav. 10(5):743-9. Zagon IS. McLaughlin PJ. Thompson CI. Learning ability in adult female rats perinatally exposed to methadone. 1979 Jun. Pharmacol Biochem Behav. 10(6):889-94. Zagon IS. McLaughlin PJ. Morphological identification and biochemical characterization of isolated brain cell nuclei from the developing rat cerebellum. 1979 Jul 20. Brain Res. 170(3):443-57. Thompson CI. Zagon IS. McLaughlin PJ. Hypophagia follows the initial hyperphagia produced by 2-deoxy-D-glucose in rats. 1979 Jul. Physiol Behav. 23(1):187-90. Thompson CI. Zagon IS. McLaughlin PJ. Imparied thermal regulation in juvenile rats following perinatal methadone exposure. 1979 Apr. Pharmacol Biochem Behav. 10(4):551-6. Zagon IS. McLaughlin PJ. Motor activity and learning ability in rats perinatally exposed to methadone. 1979. NIDA Res Monogr. 27:121-7. Zagon IS. McLaughlin PJ. Perinatal methadone exposure and its influence on the behavioral ontogeny of rats. 1978 Nov. Pharmacol Biochem Behav. 9(5):665-72. Zagon IS. McLaughlin PJ. Transplacental exposure to ethylnitrosourea and its effects on body, brain, and cerebellar development in the rat. 1978 May. Cancer Res. 38(5):1263-8. Zagon IS. McLaughlin PJ. Perinatal methadone exposure and brain development: a biochemical study. 1978 Jul. J Neurochem. 31(1):49-54. White WJ. McLaughlin PJ. Zagon IS. Effects of chronic methadone treatment on maternal body weight and food and water consumption in rats. 1978. Pharmacology. 17(4):227-32. McLaughlin PJ. Zagon IS. White WJ. Perinatal methadone exposure in rats. Effects on body and organ development. 1978. Biol Neonate. 34(1-2):48-54. Zagon IS. McLaughlin PJ. The effects of different schedules of methadone treatment on rat brain development. 1977 Sep. Exp Neurol. 56(3):538-52. Lasky DI. Zagon IS. McLaughlin PJ. Effect of maternally administered heroin on the motor activity of rat offspring. 1977 Sep. Pharmacol Biochem Behav. 7(3):281-4. Zagon IS. McLaughlin PJ. Methadone and brain development. 1977 Nov 15. Experientia. 33(11):1486-7. Zagon IS. McLaughlin PJ. Smith S. Neural populations in the human cerebellum: estimations from isolated cell nuclei. 1977 May 27. Brain Res. 127(2):279-82. Zagon IS. McLaughlin PJ. Morphine and brain growth retardation in the rat. 1977. Pharmacology. 15(3):276-82. Zagon IS. McLaughlin PJ. Effects of chronic morphine administration on pregnant rats and their offspring. 1977. Pharmacology. 15(4):302-10. Zagon IS. McLaughlin PJ. Effect of chronic maternal methadone exposure on perinatal development. 1977. Biol Neonate. 31(5-6):271-82. Smith SJ. McLaughlin PJ. Zagon IS. Granule neurons and their significance in preparations of isolated brain cell nuclei. 1976 Feb 20. Brain Res. 103(2):345-9.