Thomas Spratt All publications ( 30 ) Chen G. Dellinger RW. Sun D. Spratt TE. Lazarus P. Glucuronidation of tobacco-specific nitrosamines by UGT2B10. 2008 May. Drug Metab Dispos. 36(5):824-30. Chen KM. Spratt TE. Stanley BA. De Cotiis DA. Bewley MC. Flanagan JM. Desai D. Das A. Fiala ES. Amin S. El-Bayoumy K. Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunit. 2007 Nov 1. Cancer Res. 67(21):10475-83. Kretulskie AM. Spratt TE. Structure of purine-purine mispairs during misincorporation and extension by Escherichia coli DNA polymerase I. 2006 Mar 21. Biochemistry. 45(11):3740-6. National Cancer Institute Meyer AS. Blandino M. Spratt TE. Escherichia coli DNA polymerase I (Klenow fragment) uses a hydrogen-bonding fork from Arg668 to the primer terminus and incoming deoxynucleotide triphosphate to catalyze DNA replication. 2004 Aug 6. J Biol Chem. 279(32):33043-6. National Cancer Institute Guttenplan JB. Spratt TE. Khmelnitsky M. Kosinska W. Desai D. El-Bayoumy K. Effects of 3H-1,2-dithiole-3-thione, 1,4-phenylenebis(methylene)selenocyanate, and selenium-enriched yeast individually and in combination on benzo[a]pyrene-induced mutagenesis in oral tissue and esophagus in lacZ mice. 2004 Apr 11. Mutat Res. 559(1-2):199-210. National Cancer Institute National Institute for Dental and Craniofacial Research Washington MT. Wolfle WT. Spratt TE. Prakash L. Prakash S. Yeast DNA polymerase eta makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate. 2003 Apr 29. Proc Natl Acad Sci U S A. 100(9):5113-8. National Cancer Institute National Institute of General Medical Sciences Spratt TE. Identification of hydrogen bonds between Escherichia coli DNA polymerase I (Klenow fragment) and the minor groove of DNA by amino acid substitution of the polymerase and atomic substitution of the DNA. 2001 Mar 6. Biochemistry. 40(9):2647-52. National Cancer Institute Spratt TE. Schultz SS. Levy DE. Chen D. Schlüter G. Williams GM. Different mechanisms for the photoinduced production of oxidative DNA damage by fluoroquinolones differing in photostability. 1999 Sep. Chem Res Toxicol. 12(9):809-15. Spratt TE. Wu JD. Levy DE. Kanugula S. Pegg AE. Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase. 1999 May 25. Biochemistry. 38(21):6801-6. National Cancer Institute Wang L. Spratt TE. Pegg AE. Peterson LA. Synthesis of DNA oligonucleotides containing site-specifically incorporated O6-[4-oxo-4-(3-pyridyl)butyl]guanine and their reaction with O6-alkylguanine-DNA alkyltransferase. 1999 Feb. Chem Res Toxicol. 12(2):127-31. National Cancer Institute Nunes MG. Desai D. Koehl W. Spratt TE. Guengerich FP. Amin S. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in human hepatic microsomes by ipomeanol analogs--an exploratory study. 1998 Jul 17. Cancer Lett. 129(2):131-8. National Cancer Institute National Institute of Environmental Health Sciences Hecht SS. Spratt TE. Trushin N. Absolute configuration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol formed metabolically from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. 1997 Sep. Carcinogenesis. 18(9):1851-4. National Cancer Institute Spratt TE. Klenow fragment-DNA interaction required for the incorporation of nucleotides opposite guanine and O6-methylguanine. 1997 Oct 28. Biochemistry. 36(43):13292-7. National Cancer Institute Wang L. Spratt TE. Liu XK. Hecht SS. Pegg AE. Peterson LA. Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase. 1997 May. Chem Res Toxicol. 10(5):562-7. National Cancer Institute Spratt TE. Zydowsky TM. Floss HG. Stereochemistry of the in vitro and in vivo methylation of DNA by (R)- and (S)-N-[2H1,3H]methyl-N-nitrosourea and (R)- and (S)-N-nitroso-N-[2H1,3H]methyl-N-methylamine. 1997 Dec. Chem Res Toxicol. 10(12):1412-9. National Cancer Institute National Institute of General Medical Sciences Spratt TE. Levy DE. Structure of the hydrogen bonding complex of O6-methylguanine with cytosine and thymine during DNA replication. 1997 Aug 15. Nucleic Acids Res. 25(16):3354-61. National Cancer Institute Rosen JE. Chen D. Prahalad AK. Spratt TE. Schluter G. Williams GM. A fluoroquinolone antibiotic with a methoxy group at the 8 position yields reduced generation of 8-oxo-7,8-dihydro-2'-deoxyguanosine after ultraviolet-A irradiation. 1997 Aug. Toxicol Appl Pharmacol. 145(2):381-7. Liu XK. Spratt TE. Murphy SE. Peterson LA. Pyridyloxobutylation of guanine residues by 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone generates substrates of O6-alkylguanine-DNA alkyltransferase. 1996 Sep. Chem Res Toxicol. 9(6):949-53. National Cancer Institute Chen W. Weisburger JH. Fiala ES. Spratt TE. Carmella SG. Chen D. Hecht SS. Gastric carcinogenesis: 2-chloro-4-methylthiobutanoic acid, a novel mutagen in salted, pickled Sanma hiraki fish, or similarly treated methionine. 1996 Jan-Feb. Chem Res Toxicol. 9(1):58-66. National Cancer Institute Chen W. Weisburger JH. Fiala ES. Carmella SG. Chen D. Spratt TE. Hecht SS. Unexpected mutagen in fish. 1995 Apr 13. Nature. 374(6523):599. Spratt TE. Campbell CR. Synthesis of oligodeoxynucleotides containing analogs of O6-methylguanine and reaction with O6-alkylguanine-DNA alkyltransferase. 1994 Sep 20. Biochemistry. 33(37):11364-71. Public Health Service Hecht SS. Peterson LA. Spratt TE. Tobacco-specific nitrosamines. 1994. IARC Sci Publ. 91-106. National Cancer Institute Yang YM. Rutberg SE. Luo FC. Spratt TE. Halaban R. Ferrone S. Ronai Z. A transcriptional inhibitor induced in human melanoma cells upon ultraviolet irradiation. 1993 Jul. Cell Growth Differ. 4(7):595-602. National Cancer Institute Spratt TE. de los Santos H. Reaction of O6-alkylguanine-DNA alkyltransferase with O6-methylguanine analogues: evidence that the oxygen of O6-methylguanine is protonated by the protein to effect methyl transfer. 1992 Apr 14. Biochemistry. 31(14):3688-94. Public Health Service Carmella SG. Kagan SS. Spratt TE. Hecht SS. Evaluation of cysteine adduct formation in rat hemoglobin by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and related compounds. 1990 Sep 1. Cancer Res. 50(17):5453-9. National Cancer Institute Spratt TE. Peterson LA. Confer WL. Hecht SS. Solvolysis of model compounds for alpha-hydroxylation of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: evidence for a cyclic oxonium ion intermediate in the alkylation of nucleophiles. 1990 Jul-Aug. Chem Res Toxicol. 3(4):350-6. Public Health Service Spratt TE. Trushin N. Lin D. Hecht SS. Analysis for N2-(pyridyloxobutyl)deoxyguanosine adducts in DNA of tissues exposed to tritium-labeled 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine. 1989 May-Jun. Chem Res Toxicol. 2(3):169-73. Public Health Service Luks HJ. Spratt TE. Vavrek MT. Roland SF. Weisburger JH. Identification of sulfate and glucuronic acid conjugates of the 5-hydroxy derivative as major metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline in rats. 1989 Aug 15. Cancer Res. 49(16):4407-11. National Cancer Institute National Center for Research Resources Hecht SS. Spratt TE. Trushin N. Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine. 1988 Jan. Carcinogenesis. 9(1):161-5. Public Health Service Hecht SS. Carmella SG. Trushin N. Spratt TE. Foiles PG. Hoffmann D. Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA. 1988. IARC Sci Publ. 121-8. Public Health Service