Thomas P. Loughran
Academic title
Professor of Medicine; Director of Penn State Cancer Institute
College
College of Medicine
Campuses
Penn State Milton S. Hershey Medical Center
Department
Medicine
Graduate programs
Email
Phone
tloughran@psu.edu
717 531 4034
Educational background
M.D., Hahnemann University School of Medicine, 1979
Internship, Thomas Jefferson University Hospital
Residency, Thomas Jefferson University Hospital
Fellowship, Fred Hutchinson Cancer Research Center, University of Washington
Research interests
Large granular lymphocyte (LGL) leukemia
Retrovirus infections
Cellular immunity
Areas of expertise
Apoptosis
Myelodysplastic Syndromes
T-Lymphocytes, Cytotoxic
Killer Cells, Natural
Hematologic Neoplasms
Human T-lymphotropic virus 1
Leukemia, Prolymphocytic, T-Cell
Bone Marrow Transplantation
HTLV-I Infections
HTLV-II Infections
Anemia, Aplastic
Gene Expression Regulation
HIV Infections
Interferon-gamma
Interleukin-2
Morphine
Postoperative Complications
Fracture Fixation, Intramedullary
Knee Prosthesis
Femoral Fractures
Leukemia, Large Granular Lymphocytic
Models, Biological
Publication author name
Loughran TP Jr
Loughran TP
Select publications
Liu JH. Wei S. Lamy T. Li Y. Epling-Burnette PK. Djeu JY. Loughran TP.
Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia.
2002 Aug 15.
Blood
. 100(4):1449-53.
National Cancer Institute
Epling-Burnette PK. Liu JH. Catlett-Falcone R. Turkson J. Oshiro M. Kothapalli R. Li Y. Wang JM. Yang-Yen HF. Karras J. Jove R. Loughran TP.
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.
2001 Feb.
J Clin Invest
. 107(3):351-62.
National Cancer Institute
Loughran TP. Hadlock KG. Yang Q. Perzova R. Zambello R. Semenzato G. Foung SK. Poiesz BJ.
Seroreactivity to an envelope protein of human T-cell leukemia/lymphoma virus in patients with CD3- (natural killer) lymphoproliferative disease of granular lymphocytes.
1997 Sep 1.
Blood
. 90(5):1977-81.
National Cancer Institute
National Institute on Drug Abuse
National Heart, Lung, and Blood Institute
Loughran TP.
Clonal diseases of large granular lymphocytes.
1993 Jul 1.
Blood
. 82(1):1-14.
National Cancer Institute
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