Methotrexate
Description
  An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Synonyms
  Amethopterin
Methotrexate Hydrate
Methotrexate, (D)-Isomer
Methotrexate, (DL)-Isomer
Methotrexate, Dicesium Salt
Methotrexate, Disodium Salt
Methotrexate, Sodium Salt
Mexate
Dicesium Salt Methotrexate
Disodium Salt Methotrexate
Hydrate, Methotrexate
Sodium Salt Methotrexate
Parents
  Aminopterin
Actions
  Abortifacient Agents, Nonsteroidal
Antimetabolites, Antineoplastic
Antirheumatic Agents
Dermatologic Agents
Enzyme Inhibitors
Folic Acid Antagonists
Immunosuppressive Agents
Nucleic Acid Synthesis Inhibitors
Experts
  Stephen Benkovic
Tonya J. Crook
Harold A. Harvey
Allan Lipton
A.B. Madhankumar
Richard J. Zaino
Tree Numbers
  D03.438.733.631.192.500
MeSH ID
  D008727
also ...
 Publications