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Description |
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A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
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Synonyms |
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CD40 Antigens
Tumor Necrosis Factor Receptor Superfamily, Member 5
CD40 Antigen
CDw40 Antigen
TNFRSF5 Receptor
Antigen, CD40
Antigen, CDw40
Receptor, TNFRSF5
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Tree Numbers |
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D12.776.543.750.705.852.760.097
D23.050.301.264.035.140
D23.050.301.264.051.140
D23.101.100.110.140
D23.101.100.150.140
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