Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth. Journal   Breast cancer research : BCR. Citation   Breast Cancer Res. 3(2):122-33 Publication date   2001 Authors   Said TK Moraes RC Sinha R Medina D Investigators   Raghu Sinha Grant agencies   National Cancer Institute Grants   NCI CA-11944 MeSH headings   Antineoplastic Agents Breast Neoplasms Carrier Proteins Cell Cycle Proteins Cell Division Hydroxamic Acids MeSH qualifiers   pharmacology drug therapy drug effects Abstract   The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines. Medline ID   21148352