Inhibition of herpes simplex virus reactivation by dipyridamole. Journal   Antimicrobial agents and chemotherapy. Citation   Antimicrob Agents Chemother. 45(12):3657-9 Publication date   2001 Dec Authors   Tenser RB Gaydos A Hay KA Investigators   Richard B. Tenser Grant agencies   National Institute of Neurological Disorders and Stroke Grants   NINDS NS20684 MeSH headings   Dipyridamole Herpesvirus 1, Human Platelet Aggregation Inhibitors Virus Latency MeSH qualifiers   pharmacology drug effects Abstract   Herpes simplex virus (HSV) reactivation from latency was investigated. Reactivation of thymidine kinase-negative HSV, which is defective for reactivation, was greatly enhanced by thymidine (TdR). The reactivation-enhancing effect of TdR was blocked by dipyridamole (DPM), a known nucleoside transport inhibitor. DPM also inhibited wild-type HSV reactivation, suggesting potential antiviral use. Medline ID   21565772