Favorable outcome after infusion of coagulase-negative staphylococci-contaminated peripheral blood hematopoietic cells for autologous transplantation. Journal   Archives of pathology & laboratory medicine. Citation   Arch Pathol Lab Med. 127(1):e19-21 Publication date   2003 Jan Authors   Nifong TP Ehmann WC Mierski JA Domen RE Rybka WB Investigators   Ronald E. Domen W. Christopher Ehmann Thomas P. Nifong Witold B. Rybka MeSH headings   Coagulase Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Staphylococcus MeSH qualifiers   analysis microbiology isolation & purification Abstract   Bacterial contamination of peripheral blood hematopoietic cells collected for autologous bone marrow transplantation occurs sporadically. Although transfusion of contaminated hematopoietic cells without adverse clinical sequelae has been reported, detailed guidelines for transfusing cells with contamination are not available. We report a case of autologous hematopoietic cell transplantation that necessitated using multiple aliquots of peripheral blood hematopoietic cells known to be contaminated with coagulase-negative Staphylococcus bacteria. Prophylactic intravenous antibiotic therapy was given with the infusion of contaminated hematopoietic cells. The patient had positive results on a blood culture, but engraftment was successful, and serious adverse effects did not occur. With appropriate microbial identification and prophylactic antibiotic therapy, contaminated hematopoietic products can be safely infused when necessary with a good clinical outcome. Medline ID   22450130