Allopurinol preserves cerebral energy metabolism during perinatal hypoxia-ischemia: a 31P NMR study in unanesthetized immature rats. Journal   Neuroscience letters. Citation   Neurosci Lett. 144(1-2):103-6 Publication date   1992 Sep 14 Authors   Williams GD Palmer C Heitjan DF Smith MB Investigators   Charles Palmer Michael B. Smith MeSH headings   Allopurinol Brain Chemistry Brain Ischemia Energy Metabolism Hypoxia, Brain MeSH qualifiers   pharmacology drug effects metabolism Abstract   The effects of high dose allopurinol (ALLOP) pretreatment on the cerebral energy metabolism of unanesthetized 7-day-postnatal rats during exposure to 3 h of cerebral hypoxia-ischemia were serially quantitated using non-invasive 31P NMR spectroscopy. Adenosine triphosphate, integrated over the last 2 h of hypoxia and expressed as a fraction of baseline, was 0.73 +/- 0.16 with ALLOP pretreatment (200 mg/kg s.c.) compared to 0.52 +/- 0.05 for saline pretreatment (P = 0.001). Inorganic phosphate/phosphocreatine (Pi/PCr), integrated over the same time interval, was 2.63 +/- 1.23 relative to baseline with ALLOP versus 5.13 +/- 1.45 for saline-treated pups (P less than 0.0005). We suggest that the neuroprotection achieved with high dose ALLOP pretreatment may be attributed in part to preservation of energy metabolites. Medline ID   93064145