DED: Database of Evolutionary Distances. Journal   Nucleic acids research. Citation   Nucleic Acids Res. 33(Database issue):D442-6 Publication date   2005 Jan 1 Authors   Veeramachaneni V Makalowski W Investigators   Wojciech Makalowski MeSH headings   Databases, Genetic Evolution, Molecular Phylogeny Sequence Homology Abstract   A large database of homologous sequence alignments with good estimates of evolutionary distances can be a valuable resource for molecular evolutionary studies and phylogenetic research in particular. We recently created a database containing 159,921 transcripts from human, mouse, rat, zebrafish and fugu species. Approximately 1,000 homology groups were identified with the help of Ensembl homology evidence. At the macro-level, the database allows us to answer queries of the form: 1. What is the average k-distance between 5' untranslated regions of human and mouse? 2. List the 10 groups with the highest K(a)/K(s) ratio between mouse and rat. 3. List all identical proteins between human and rat. Researchers interested in specific proteins can use a simple web interface to retrieve the homology groups of interest, examine all pairwise distances between members of the group and study the conservation of exon-intron gene structures using a graphical interface. The database is available at http://warta.bio.psu.edu/DED/.