Simulation of ozone uptake distribution in the human airways by orthogonal collocation on finite elements. Journal   Computers and biomedical research, an international journal. Citation   Comput Biomed Res. 25(3):264-78 Publication date   1992 Jun Authors   Hu SC Ben-Jebria A Ultman JS Investigators   Abdellaziz Ben-Jebria James Ultman MeSH headings   Models, Biological Ozone Respiratory Physiology Respiratory Transport MeSH qualifiers   metabolism Abstract   Ozone transport in a rigid single-pathway anatomic model of the lung was analyzed by a stable convergent numerical algorithm, the method of orthogonal collocation on finite elements. The simulations predicted the dynamic behavior of gas phase concentration profiles for both ozone and an insoluble inert gas. An internal quasi-stationary diffusion front was observed during early inspiration for both gases. In addition, the absorptive distribution of ozone in lung airways was computed as a total dose as well as a tissue dose. The total dose of ozone decreased along the airway path from the mouth. However, the tissue dose of ozone increased along the conducting airways, reached a maximal dose in the terminal bronchioles, and decreased sharply in the respiratory airways. Medline ID   92306696